Is abrin toxic?

Is abrin toxic?

Abrin is a natural poison that is found in the seeds of a plant called the rosary pea or jequirity pea. These seeds are red with a black spot covering one end. Abrin is similar to ricin, a toxin that also is found in the seeds of a plant (the castor bean plant).

What is jequirity used for?

Jequirity leaves are taken by mouth for fever, cough, common cold, flu, insect bites, and gonorrhea. Despite serious safety concerns, women use jequirity bean to speed up labor, to cause an abortion, or to prevent pregnancy. Jequirity bean is also used as a painkiller in terminally ill patients.

Are jequirity leaves poisonous?

Jequirity is a climbing plant. The roots, leaves, and beans have been used as medicine. Jequirity is poisonous. Despite serious safety concerns, some people take jequirity by mouth for asthma, constipation, liver disease, and other conditions.

How poisonous are rosary peas?

Rosary pea is highly toxic and can be fatal if ingested. In its native range, the roots are used to induce abortion and relieve abdominal discomfort. One of the most deadly plant toxins, abrin, is produced by rosary pea.

Is abrin more toxic than ricin?

Abrin is a protein-based toxin from the jequirity bean, colloquially known as a rosary bead. The toxin is lethal in minute doses and causes serious symptoms in even smaller amounts. It is almost identical to a better-known toxin—ricin. Abrin is more lethal than ricin.

Is abrin poisonous to dogs?

Mice and dogs, were treated iv with the cytostatic proteins abrin and ricin and observed for clinical, biochemical, and morphological aberrations. In both mice and dogs death occurred within a narrow dose range. Dogs given toxic doses of ricin and abrin showed weakness, anorexia, apathy, and moderate fever.

How much abrin is in a rosary pea?

The usual fatal dose of ‘rosary pea’ ranges from 90 to 120 mg (1–3 seeds) though a single chewed jequirity seed may be fatal in either adult or child. The abrin content of Abrus precatorious seeds is about 0.15% w/w.

Where is jequirity found?

jequirity bean, (Abrus precatorius), also called rosary pea, or Indian licorice, plant of the pea family (Fabaceae), found in tropical regions. The plant is sometimes grown as an ornamental and is considered an invasive species in some areas outside its native range.

What is abrin and ricin?

Ricin and abrin are potent biological toxins that are derived from plant sources (castor beans and rosary peas, respectively). More is known about ricin toxicity; however, abrin toxicity is similar in its mechanism of action. In the body, these toxins inhibit protein synthesis leading to cell death.

How much abrin is lethal?

0.1-1 microgram/kg
Abrin is a toxic protein obtained from the seeds of Abrus precatorius (jequirity bean), which is similar in structure and properties to ricin. Abrin is highly toxic, with an estimated human fatal dose of 0.1-1 microgram/kg, and has caused death after accidental and intentional poisoning.

Can abrin be detected?

Among the currently used detection methods for abrin, antibody-based enzyme-linked immunosorbent assays (ELISAs) remain the standard technique, and are widely used to detect abrin in environmental and food samples.