What are the 3 hematopoietic cell lines?
Hodgkin’s disease, ALCL and dendritic cell lines Commonly the assignment of any given hematopoietic cell line to a cell lineage and stage of arrested differentiation, based on its immunological and other phenotypes, does not present any problems.
What is the function of a hematopoietic cell?
Hematopoietic stem cells (HSCs) are responsible for the production of mature blood cells in bone marrow; peripheral pancytopenia is a common clinical presentation resulting from several different conditions, including hematological or extra-hematological diseases (mostly cancers) affecting the marrow function, as well …
How are hematopoietic cells made?
Hematopoiesis in the embryo As the embryo continues to develop, the hematopoiesis process moves to the liver, the spleen, and bone marrow, and begins producing other types of blood cells. In adults, hematopoiesis of red blood cells and platelets occurs primarily in the bone marrow.
What is Lin immunology?
Lineage Negative (Lin-) Markers Note A select list of Lin- markers are provided as examples of markers that have been used in the literature to exclude particular lineages of cells in order to help identify the cell type of interest.
What are hematopoietic progenitor cells?
Hematopoietic progenitor cells (HPCs) are an intermediate cell type in blood cell development. HPCs are immature cells that develop from hematopoietic stem cells, cells that can both self-renew and differentiate into hematopoietic progenitor cells.
What is hematopoiesis in simple words?
: the formation of blood or of blood cells in the living body.
What is a hematopoietic stem cell?
Hematopoietic stem cells (HSCs) have the capacity to self-renew and the potential to differentiate into all of the mature blood cell types. The ability to prospectively identify and isolate HSCs has been the subject of extensive investigation since the first transplantation studies implying their existence almost 50 years ago.
How to detect human hematopoietic cells in mouse bone marrow?
Detection of human hematopoietic cells in mouse bone marrow: Mice are euthanized under inhalation isoflurane anesthesia by cervical dislocation at or greater than 6 weeks post-transplantation. Single-cell bone marrow suspensions are prepared by flushing the femurs and tibiae with PBS containing 2% FBS using a 21-gauge needle.
Are primitive human hematopoietic cells enriched in cord blood?
Primitive human hematopoietic cells are enriched in cord blood compared with adult bone marrow or mobilized peripheral blood as measured by the quantitative in vivo SCID-repopulating cell assay. Blood. 1997;89:3919–3924. [PubMed] [Google Scholar]
What is the structure of the hematopoietic stem compartment?
The hematopoietic stem compartment consists of a limited number of discrete stem cell subsets. Blood. 2006;107:2311–2316. [PMC free article][PubMed] [Google Scholar] Smogorzewska A, de Lange T. Regulation of telomerase by telomeric proteins.