What are the histopathological features of celiac disease?
Typically, coeliac disease is characterised by the triad of histological features: 1) intraepithelial lymphocytosis (IEL>30/100 epithelial cells), 2) lamina propria inflammation, and 3) villous atrophy.
What does HLA-DQ2 stand for?
Celiac disease is a genetic condition, which means you need to have the “right” genes to develop it and be diagnosed with it. HLA-DQ2 is one of two main celiac disease genes, and happens to be the most common gene implicated in celiac disease (HLA-DQ8 is the other so-called “celiac gene”).
What causes crypt hyperplasia?
Crypt hyperplasia Elongation may be caused by expansion of the lamina propria as a result of the proliferation of stromal cells,81 an influx of inflammatory cells50 and tissue remodelling.
Why is it called celiac?
Some 8,000 years after its onset, celiac disease was identified and named. A clever Greek physician named Aretaeus of Cappadocia, living in the first century AD, wrote about “The Coeliac Affection.” In fact, he named it “koiliakos” after the Greek word “koelia” (abdomen).
What is the pathophysiology of celiac disease?
Celiac disease is characterized by small intestinal mucosal injury and nutrient malabsorption in genetically susceptible individuals following the dietary ingestion of “gluten.” The pathogenesis of disease involves interactions between environmental, genetic, and immunologic factors.
What is characteristic of the intestine of a patient newly diagnosed with celiac disease?
It is believed that there is an immunological response to components of gluten which result in inflammation of the lining of the small intestine which is characterized by flattening of the finger-like projections (villi).
What is HLA-DQ2 positive?
If the test results are positive for HLA DQ2 or DQ8, your child is at risk of developing celiac disease. It doesn’t mean they will definitely have celiac disease and the chance of developing celiac disease is still low.
What is DQ2 positive?
The risk for celiac disease in patients who are positive for DQ2 or DQ8 can be determined based on which molecules are encoded. DQ2. 5 is most highly associated with celiac disease, while DQ8 and DQ2. 2 are associated with a lower risk.
What does crypt hyperplasia Mean?
Crypt hyperplasia is when the grooves are elongated compared to a normal intestinal lining which has short crypts. Blunted or atrophic villi. This is a shrinking and flattening of the villi due to repeated gluten exposure. Mononuclear cell infiltration in the lamina propria.
What are crypts in small intestine?
Crypts (of Lieberkuhn) are moat-like invaginations of the epithelium around the villi, and are lined largely with younger epithelial cells which are involved primarily in secretion.