What is the mechanism of action of lisinopril?

What is the mechanism of action of lisinopril?

Lisinopril inhibits an enzyme called angiotensin-converting enzyme (ACE). This enzyme is involved in the production of angiotensin II, a powerful vasoconstrictor (a substance that narrows the arteries), which also stimulates the release of the hormone, aldosterone, from the adrenal glands (aldosterone increases blood pressure).

Is it possible to reduce the dose of lisinopril?

After the addition of a diuretic, it may be possible to reduce the dose of lisinopril. -In all high risk patients, such as patients with ischemic heart or cerebrovascular disease, in whom excessive falls in blood pressure may lead to myocardial infarction or cerebrovascular accident the manufacturer advises treatment initiation at lower dosages.

Is Lisinopril an ACE inhibitor?

Lisinopril is an ACE inhibitor. ACE stands for angiotensin converting enzyme. Lisinopril is used to treat high blood pressure (hypertension) in adults and children who are at least 6 years old.

How do I report side effects of lisinopril in Canada?

In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. Before taking lisinopril, tell your doctor or pharmacist if you are allergic to it; or to other ACE inhibitors (such as benazepril); or if you have any other allergies.

While the mechanism through which Lisinopril lowers blood pressure is believed to be primarily suppression of the renin-angiotensin-aldosterone system, Lisinopril is antihypertensive even in patients with low-renin hypertension.

Does lisinopril block angiotensin II?

Surgery/Anesthesia. In patients undergoing major surgery or during anesthesia with agents that produce hypotension, Lisinopril may block angiotensin II formation secondary to compensatory renin release. If hypotension occurs and is considered to be due to this mechanism, it can be corrected by volume expansion.

What is the oral bioavailability of lisinopril in congestive heart failure?

The absolute bioavailability of Lisinopril is reduced to 16% in patients with stable NYHA Class II-IV congestive heart failure, and the volume of distribution appears to be slightly smaller than that in normal subjects. The oral bioavailability of Lisinopril in patients with acute myocardial infarction is similar to that in healthy volunteers.

When to stop taking lisinopril for high blood pressure?

If prolonged hypotension occurs (systolic blood pressure < 90 mmHg for more than 1 hour) Lisinopril should be withdrawn. No dose adjustment of Lisinopril is required in patients with creatinine clearance > 30 mL/min.