What is thiola 100mg?

What is thiola 100mg?

THIOLA is a prescription medicine. It is used in combination with high fluid intake, alkali (low acid), and dietary changes to help prevent the formation of one type (cystine) of kidney stone in certain adult and pediatric patients that weigh at least 44 pounds (20 kg) and who do not respond to these measures alone.

Is there a generic for thiola?

No. There is currently no therapeutically equivalent version of Thiola EC available in the United States. Note: Fraudulent online pharmacies may attempt to sell an illegal generic version of Thiola EC. These medications may be counterfeit and potentially unsafe.

What is thiola used for?

This medication is used to prevent kidney stones in people with a certain inherited disorder (cystinuria). Cystinuria occurs when there is too much of a certain natural substance (the amino acid cystine) in the urine, leading to formation of kidney stones.

Who makes thiola?

Retrophin Announces FDA Approval of THIOLA® EC (tiopronin) 100mg and 300mg Tablets for the Treatment of Cystinuria. SAN DIEGO, June 28, 2019 (GLOBE NEWSWIRE) — Retrophin, Inc.

What causes cystinuria?

Cystinuria is caused by too much cystine in the urine. Normally, most cystine dissolves and returns to the bloodstream after entering the kidneys. People with cystinuria have a genetic defect that interferes with this process. As a result, cystine builds up in the urine and forms crystals or stones.

How long does it take potassium citrate to work?

Overall a significant and durable change in urinary metabolic profiles was noted as soon as 6 months after the onset of therapy. These changes included increased urinary pH (5.90 to 6.46, p <0.0001) and increased urinary citrate (470 to 700 mg a day, p <0.0001).

How do I know if I have cystinuria?

Signs & Symptoms The initial symptom of cystinuria is usually sharp pain in the lower back or side of the abdomen (renal colic). Other symptoms may include blood in the urine (hematuria), obstruction of the urinary tract, and/or infections of the urinary tract. Frequent recurrences ultimately may lead to kidney damage.

How do you reduce cystine in urine?

What is the treatment for cystinuria?

  1. Drinking more water. Drinking lots of water will lower the ability for the cystine to form stones in the urine.
  2. Changing your diet. Cystine stones are less able to form in urine that is less acidic.
  3. Reducing salt. Eating less salt can help keep cystine stones from forming.
  4. Medicine.

Can I take potassium citrate every day?

Adults—At first, 15 to 30 milliequivalents (mEq) two times a day, or 10 to 20 mEq three times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 100 mEq per day. Children—Use and dose must be determined by your doctor.

What type of drug is Thiola?

THIOLA (tiopronin) immediate-release tablets are a reducing and cystine-binding thiol drug (CBTD) for oral use. Tiopronin is N- (2-Mercaptopropionyl) glycine and has the following structure: Tiopronin has the empirical formula C 5 H 9 NO 3 S and a molecular weight of 163.20. In this drug product tiopronin exists as a dl racemic mixture.

Is there a copay for Thiola 300 mg?

Larger dosage strength—300 mg—may help reduce pill burden. Freedom to take your dose before, during, or after meals. $0 copay for eligible, commercially insured patients. † † See full Copay Terms and Conditions. Make sure your doctor includes Dispense As Written (DAW) on your prescription form. Interested in THIOLA (tiopronin)?

What is the average dose of Thiola ®?

In a multiclinic trial, average dose of THIOLA ® was about 1000 mg/day. However, some patients require a smaller dose. In children, initial dosage may be based on 15 mg/kg/day. Urinary cystine should be measured at 1 month after THIOLA ® treatment, and every 3 months thereafter.

Is Thiola an active reducing agent?

Thiola Tablets – Clinical Pharmacology. THIOLA ® is an active reducing agent which undergoes thiol-disulfide exchange with cystine to form a mixed disulfide of Thiola-cysteine. From this reaction, a water-soluble mixed disulfide is formed and the amount of sparingly soluble cystine is reduced.