Does streptomycin inhibit cell wall synthesis?
Streptomycin and its related antibiotics bind tightly to the protein component of the 30S subunit that normally receives IF3, and initiation of protein synthesis is thus inhibited. It appears that the synthesis of large amounts of toxic, non-functional proteins is very detrimental to cell life.
Why is streptomycin not given orally?
Humans have structurally different ribosomes from bacteria, thereby allowing the selectivity of this antibiotic for bacteria. Streptomycin cannot be given orally, but must be administered by regular intramuscular injection. An adverse effect of this medicine is ototoxicity. It can result in permanent hearing loss.
What bacteria is resistant to streptomycin?
Most acquired bacterial resistance to streptomycin is due to mutations in the rpsL (Ribosomal Protein Small subunit) gene. This gene encodes ribosomal protein S12. These researchers isolated streptomycin resistant strains of E. coli K-12 by growth on streptomycin-containing agar plates (50 μg/ml).