How long is meropenem good for after reconstitution?

How long is meropenem good for after reconstitution?

Following reconstitution (activation) in the DUPLEX® Container, the product maintains satisfactory potency for 1 hour at up to 25ºC (77ºF) or for 15 hours at up to 5ºC (41ºF). Solutions of intravenous Meropenem for Injection USP and Sodium Chloride Injection USP should not be frozen.

Does meropenem need to be refrigerated?

Meropenem as the trihydrate in elastomeric administration devices displays reasonable stability at lower concentrations (6 mg/mL and 12 mg/mL), under refrigerated conditions (6.7°C).

Is meropenem a reconstitution?

Meropenem to be used for bolus intravenous injection should be reconstituted with sterile water for injection. For intravenous infusion, meropenem vials may be directly reconstituted with 0.9 % sodium chloride or 5% glucose solutions for infusion. Each vial is for single use only.

How long is meropenem stable for?

Conclusion: Meropenem 4 mg/mL in NS was stable for at least seven days in PVC bags and elastomeric infusion containers when stored at 5° C, and meropenem 10 and 20 mg/mL in NS was stable for at least five days in both containers at 5° C.

Can meropenem run with lactated ringers?

Compatibility: Solutions Compatible: D5W, 0.9%NS, D5NS, ringer’s solution, ringer’s lactate.

Is meropenem a strong antibiotic?

Meropenem (Merrem) is considered one of the stronger antibiotics. It works against many types of bacteria and treats severe or complicated infections when other antibiotics may not be enough.

Can I dilute meropenem?

STEP ONE: Add 9.6mL of water for injection to the meropenem 500mg vial and shake gently to dissolve (total volume of 10mL). The resulting solution contains 50mg/mL meropenem.

How fast can meropenem be given IV?

aeruginosa, a dose of 1 gram every 8 hours is recommended. MERREM IV should be administered by intravenous infusion over approximately 15 minutes to 30 minutes. Doses of 1 gram may also be administered as an intravenous bolus injection (5 mL to 20 mL) over approximately 3 minutes to 5 minutes.

What is the optimum pH for meropenem stability?

Meropenem stability has been shown to be influenced by temperature, 7 pH 10 11 and drug concentration. 7 12 The apparent optimum pH for stability is approximately pH 6. 7 Degradation rates also increase at higher concentrations, which is of particular relevance when treating multidrug-resistant infections.

How stable is meropenem in elastomeric infusion devices?

This study found that at lower concentrations of 6 mg/mL, meropenem showed suitable stability for storage and administration in elastomeric infusion devices, maintaining >90% of its initial concentration for up to 144 hours when stored at 6.7°C and 72 hours following 24 hours storage at 22.5°C (having been initially refrigerated for 48 hours).

How long can meropenem be stored at room temperature?

Stability: Meropenem injection vials constituted with sterile Water for Injection for bolus administration (up to 50 mg/mL of Meropenem) may be stored for up to 2 hours at controlled room temperature 15-25°C (59-77°F) or for up to 12 hours at 4°C (39°F).

Can meropenem be re-constituted with dextrose?

Solutions prepared for infusion (Meropenem concentrations ranging from 1 mg/mL to 20 mg/mL) re-constituted with Dextrose Injection 5% should be used immediately. See warnings and precautions below. Meropenem for injection is a sterile, pyrogen-free, synthetic, carbapenem antibacterial drug for intravenous administration.