What is IgG subclasses test?
Measurement of IgG subclass concentrations is a standard laboratory test run as part of a panel to investigate the suspicion of antibody deficiency. The assessment is clinically important when total IgG is within the normal age-specific reference range.
What are subtypes of IgG?
IgG is composed of four subclasses: IgG1, IgG2, IgG3, and IgG4 [1-9].
What is an IgG subclass 4 blood test for?
Optimal Result: 4 – 86 mg/dL. This marker helps to evaluate sinopulmonary infections, asthma; immunotherapy hyposensitization; and allergies. IgG immunoglobulins are composed of four subtypes named IgG1, IgG2, IgG3 and IgG4.
What do IgG test results mean?
Your doctor can test for IgG to figure out whether you’ve been infected by certain kinds of bacteria or virus. Immunoglobulin M: Your body makes IgM antibodies when you are first infected with new bacteria or other germs. They are your body’s first line of defense against infections.
Why would a doctor order a IgG test?
An immunoglobulins blood test may be used to help diagnose a variety of conditions, including: Bacterial or viral infections. Immunodeficiency, a condition that reduces the body’s ability to fight infections and other diseases. An autoimmune disorder, such as rheumatoid arthritis or lupus.
What are normal IgG subclass levels?
IgG Subclass Reference Ranges
|Test/Age||IgG Subclass Reference Ranges (mg/dL)|
|1 – 3 years||15 – 80|
|3 – 12 years||10 – 120|
|12 – 16 Years||20 – 150|
|>16 years||20 – 170|
What is the difference between IgG subclasses?
Another structural difference between the human IgG subclasses is the linkage of the heavy and light chain by a disulfide bond. This bond links the carboxy-terminal cysteine of the light chain to the cysteine at position 220 (in IgG1) or at position 131 (in IgG2, IgG3, and IgG4) in the CH1 domain (Figure 2A).
What does IgG subclass 3 mean?
Therefore, a person lacking a specific IgG subclass will be vulnerable to certain kinds of infections but not others. For example, the IgG1 and IgG3 subclasses contain antibodies against serious bacterial infections such as diphtheria and tetanus, as well as antibodies against viral proteins.
What is IgG test for Covid?
This is a blood test. It is designed to detect IgG antibodies specific for the virus spike protein that develop once a person has received the COVID-19 vaccination. It is intended to confirm that a person has developed the antibodies that protect a person from getting a severe COVID-19 infection or hospitalization.