Which is called a pleiotropic gene?
Which is called a pleiotropic gene?
Pleiotropic gene: A gene that affects more than one phenotype. Pleiotropy results in different expressions at the phenotypic level. For example, sickle cell anaemia and cystic fibrosis in man.
Who discovered pleiotropic gene?
Pleiotropy is defined as the phenomenon in which a single locus affects two or more distinct phenotypic traits. The term was formally introduced into the literature by the German geneticist Ludwig Plate in 1910, 100 years ago.
Which one is the example for pleiotropy?
Pleiotropy Examples An example of pleiotropy that occurs in humans is sickle cell disease. Sickle cell disorder results from the development of abnormally shaped red blood cells.
Why is pleiotropy so common?
We have known for decades that pleiotropy is widespread because in plant and animal breeding, and in laboratory selection experiments, when selection is applied to one trait, the mean of other traits also changes from generation to generation.
What effect does pleiotropy have on gene expression?
What effect does pleiotropy have on gene expression? A. Pleiotropy can cause a mutation in a normal allele.
What are the human diseases caused by pleiotropy?
Deafness and pigmentation in cats, the existence of frizzle traits in cats, Marfan syndrome in humans, sickle cell diseases, Phenylketonuria or PKU, albinism, Austin, and schizophrenia are some of the many examples of pleiotropic.
How does pleiotropy is different from multiple allele?
When more than two alternate forms of a gene are found on the locus, it is known as multiple alleles. While pleiotropic genes are genes having multiple phenotypic effects due to their ability to regulate the expression of a number of traits known as pleiotropic genes.
Are all genes pleiotropic?
Frequency of Pleiotropy A total of 233 genes were defined as pleiotropic (16.9% of all genes in the catalog).
Are most genes technically pleiotropic?
Very likely, most genes have some pleiotropic effects. In a biological system as complex as human beings, it’s really hard to design a stretch of DNA that specifically alters one attribute of our physiology or appearance without also having some side effects. That has interesting consequences for evolution.
How to pronounce pleiotropy?
Break ‘pleiotropy’ down into sounds : say it out loud and exaggerate the sounds until you can consistently produce them.
What are some examples of pleiotropy?
Pleiotropy Definition. Pleiotropy is defined as a phenomenon in which a single gene controls or affects many phenotypic traits.
What is pleiotropy in genetics?
Pleiotropy is the genetic phenomenon in which the expression of a gene affects in an individual the phenotypic manifestation of other unrelated characters. Etymologically, pleiotropy means “more changes” or “many effects” that is, more effects than expected from the expression of a single gene.